By Professor Liang-tseng Fan, Dr. Satish Kumar Singh (auth.)
The proposal of managed liberate has attracted expanding realization over the past 20 years, with the purposes of this know-how proliferating in assorted fields in cluding drugs, agriculture and biotechnology. study and developmental efforts regarding managed unencumber are multiplying in either and academia. the cause of this out of the ordinary progress is apparent. using quite a few biologically energetic brokers, equivalent to medicinal drugs, fertilizers and insecticides, has turn into a vital part of recent society. in addition to using those reagents has advanced an know-how that their out of control software virtually necessarily induces damaging results at the wellbeing and fitness of people and their surrounding environments. To dispose of or reduce those damaging results necessitates the managed free up of those chemical compounds. in addition, the managed free up of gear, now not often thought of poisonous or harmful, e.g., a few catalysts and food, can improve their effectiveness. The quantity and diversity of managed liberate structures, differing of their actual and chemical make-up, are expanding speedily. Proliferation commonly calls for correlation, generalization and unification; it calls for either the improvement of underlying theories in their habit and the mechanistic interpretation in their functionality. This, in flip, calls for a statistical and mathematical (quantitative) therapy of the clinical info and technical information bearing on them. A quantitative remedy may also facilitate the formula of approaches for computer-aided layout of those structures via a priori prediction in their in step with formance for numerous layout parameters.
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Extra info for Controlled Release: A Quantitative Treatment
An example of the influence of the partition coefficient on release characteristics is given in Fig. 16 for release of micro-sized ethynodiol diacetate from silicone elastomer matrix devices to an elution medium containing poly(ethylene glycol) (PEG) 400. The partition coefficient is seen to significantly affect the rate of release. , 1985b). 1 to 1) also has resulted in a change in the rate controlling mechanism from the matrix-diffusion controlled to the elution medium-polymer partition controlled (Chien and Lambert, 1974).
00 Membrane thickness r1 /rZ Sphere: Cylinder: r2 r1 (dM t ) = 47TDKC sm - rz- r1 dt r t ) = 2 7T DKC sm -h(dM -dt r In(r2 /r1 ) ; 47TDK =1 27TDK = 112 Fig. 23. 5 dependent on whether the active agent is simply dissolved (Fig. 24a) or dispersed in the matrix (Fig. 24 b; simple monolithic dispersions only). In addition to the three common geometries, special geometries have been devised to obtain constant release rates. , 1980b) and sectioned-cylinder (Brooke and Washkuhn, 1977) geometries. The objective of the special geometries is to create an increasing area over which the active agent dissolves into the polymer as the diffusion distance increases (Fig.
1 Diffusion in Polymers Drug o R21 R" RI7 H OH H H OH OH OH H H OH H OH H OH H H H OH H OH OH Fig. 17. , 1987) the influence of varying the number and position of OH groups in progesterone on its partitioning between a saline-PEG 400 medium and skin. The results are shown in Fig. 17 as solubility in the skin versus the progesterone derivatives, and the effect is significant. The importance of the size of a solute molecule is evident in the plot of solubility against the molar volume of the condensed vapor for sorption in polyethylene (Fig.
Controlled Release: A Quantitative Treatment by Professor Liang-tseng Fan, Dr. Satish Kumar Singh (auth.)