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New PDF release: Chromosomal Translocations and Oncogenic Transcription

By P. M. Waring (auth.), Frank J. Rauscher III Ph.D., Peter K. Vogt Ph.D. (eds.)

ISBN-10: 364260479X

ISBN-13: 9783642604799

ISBN-10: 3642644244

ISBN-13: 9783642644245

Regulation of gene expression on the point of transcription is among the significant determinants of right mobile proliferation and differentiation. the main avid gamers in those strategies are sequence-specific DNA binding transcription issue proteins which coordinate courses of gene expression within the nucleus. The articles during this quantity record the myriad of genetic and biochemical changes sustained by way of human proto-oncogenic transcription elements which lead to various neoplastic tactics. This quantity supplies insights into how basic courses of gene expression might be subverted through the motion of unmarried transcription elements leading to a particular tumor style. The ebook presents thought for exploiting those tumor-specific adjustments as diagnostic, prognostic instruments, or as selective healing targets.

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Additional info for Chromosomal Translocations and Oncogenic Transcription Factors

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Genes Dev 8: 2478-2490 Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR (1994) Nucleosome disruption and enhancement of activator binding by a human SWI/SNF complex. Nature 370: 477-481 Lanza C, Gaidano G, Cimino G, Lo Coco F, Basso G, Sainati L, Pastore C, Nomdedeu J, Volpe G, Parvis G, Barisone E, Mazza V, Madon E, Saglio G (1995) p53 gene inactivation in acute lymphoblastic leukemia of B cell lineage associates with chromosomal breakpoints at IIq23 and 8q24. Leukemia 9: 955-959 Leblanc T, Hillion J, Derre J, Le Coniat M, Baruchel A, Daniel MT, Berger R (1994) Translocation t(Il;Il)(qI3;q23) and HRX gene rearrangement associated with therapy-related leukemia in a child previously treated with VP16.

Stippled regions represent E2A sequences and open regions represent Pbxi sequences. The Pbxi homeodomain. indicated by " Pbx] HD", is blackened. and the unique COOH-terminal sequence of Pbx ib is designated by a cross-hatched region. B Comparison of the homebox genes contained in the Drosophila HOM-C complex with homologues contained in the four murine Ho x gene clusters. The boxes representing Hox genes proven to exhibit cooperative binding with Pbxi are stippled et al. 1989), and it is strongly expressed in the B cell lineage.

P. Kamps suggests that it may be oncogenic because it activates transcription of Pbx1 target genes. Differential mRNA splicing produces two forms of Pbx1 in normal cells (Pbx1a and Pbx1b) and two forms of E2A-Pbx1 in pre-B ALL cells (E2A-Pbxla and E2A-Pbxlb; KAMPS et al. 1991; NOURSE et al. 1990). 4 The PBX Gene Family and Interspecies Homologues PBXI is one member of a family of vertebrate homeobox genes that include PBX2 and PBX3 (MONICA et al. 1991). Pbx1 exhibits 94% sequence identity with Pbx2 and Pbx3 between residues 40 and 315, but diverges substantially from Pbx2 and Pbx3 at its NH 2-terminal and COOH-terminal ends.

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Chromosomal Translocations and Oncogenic Transcription Factors by P. M. Waring (auth.), Frank J. Rauscher III Ph.D., Peter K. Vogt Ph.D. (eds.)

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