By Institute of Medicine, Board on Global Health, Forum on Microbial Threats, Alison Mack, David A. Relman, Eileen R. Choffnes
Years of utilizing, misusing, and overusing antibiotics and different antimicrobial medicinal drugs has resulted in the emergence of multidrug-resistant 'superbugs.' The IOM's discussion board on Microbial Threats held a public workshop April 6-7 to debate the character and resources of drug-resistant pathogens, the results for worldwide overall healthiness, and the thoughts to minimize the present and destiny effect of those superbugs.
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Extra info for Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies: Workshop Summary
Resistance genes are apparently ubiquitous among bacterial genomes, as Davies and Wright noted. word=insertion+sequence+(IS) [accessed June 14, 2010]). Mobile DNA elements that can capture and carry genes, particularly those responsible for antibiotic resistance. articlekey=32273 [accessed June 14, 2010]). everythingbio. word=transposon [accessed June 14, 2010]). s=plasmid [accessed June 14, 2010]). word=conjugation [accessed June 14, 2010]). Copyright © National Academy of Sciences. All rights reserved.
The extent of this harm remains to be determined, however, along with other potential outcomes of the Danish experiment, such as whether this attempt to reduce the non-therapeutic use of antimicrobials in food animals has resulted in fewer resistant bacterial infections in humans. Antimicrobial Treatment of Crop Plants Fungi and viruses pose a greater threat to most crop plants than bacteria (Vidaver, 2002). Selective breeding of plants for disease resistance has reduced, but not eliminated, the economic impacts of several fungal and viral plant pathogens.
Leaving aside the problems of quantification, Laxminarayan considered several important trends in AMR development and impact, and what they imply for the next 5 to 10 years. In the United States and other developed countries, he predicted, increasing AMR is likely to raise healthcare costs, but not necessarily mortality, as physicians substitute newer, more expensive drugs as first-line therapy for resistant infections (often without evidence that it is needed). Meanwhile, he said, combined increases in wealth and access to antimicrobials in developing Copyright © National Academy of Sciences.
Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies: Workshop Summary by Institute of Medicine, Board on Global Health, Forum on Microbial Threats, Alison Mack, David A. Relman, Eileen R. Choffnes